I published a long-term vitamin supplement D increasing the risk of dementia by 2 times the risk of dementia death. After that, several readers responded, hoping that I can further explain the activity/inactivity. First of all, the news report quote...
I published a long-term vitamin supplement D increasing the risk of dementia by 2 times the risk of dementia death. After that, several readers responded, hoping that I can further explain the activity/inactivity.
First of all, the news report quoted in this article I published the day before yesterday pointed out that the research of the National Institute of Health in Taiwan analyzes the consequences of taking prescription active vitamin D3 (calcitriol). However, the research paper published by the National Institute of Health did not discuss the difference between active and inactive vitamin D3, so I did not discuss this on my own.
The vitamin D I published two years ago was invalid because I was eating it? There are a few sentences: [Whether it is from sunlight or from food, vitamin D is inactive. They transform into Calcifediol (calcitriol) in the liver, and then further transform into Calcitriol (calcitriol) in the kidney. This calcitriol has physiological effects, such as increasing the ability of the kidney to absorb calcinia, so it is called "active vitamin D". Calcitriol is an anti-preventive medicine and is used to prevent and treat certain parathral glands and kidney diseases. It is 100% certain that all "vitamin D supplement clinical trials" are made with "inactive vitamin D". So, when I published an article saying that vitamin D is invalid, I mean "inactive vitamin D", which is the vitamin D that ordinary people eat. 】
Regarding the relationship between vitamin D supplementation and dementia, the latest and largest clinical study was the Effect of vitamin D on cognitive decline: results from two ancillary studies of the VITAL randomized trial, published on December 1 last year.
This research was led by a research team at Harvard University, so it is also credible. More importantly, this paper reviewed the relevant clinical research done by other research teams in Discussion. In other words, you can fully understand whether supplementing vitamin D can improve or reduce the risk of dementia by reading this discussion. Please note that all these clinical institutes explored "inactive vitamin D". I now translate the discussion of this article as follows:
In this 2-3-year random trial for elderly people living in communities with general health, supplementing 2,000 IU of vitamin D3 per day has nothing to do with degraded cognitive ability. No impact was observed in both substudy of language memory, executable function/attention, and overall awareness, as well as in both substudy of evaluating aware by phone or self-evaluation.
However, a pre-specified assemblage analysis showed that Vitamin D3 supplementation had an aware benefit to the consolation agent in black participants at any time, but this had nothing to do with the 25(OH)D level. Since Asian analysis by race may be a coincidence, this result should be carefully explained and proved in future studies.
Random trials of vitamin D and decreased cognitive ability have been consistently found in relatively healthy people. Although vitamin D has potential neuroprotective anti-inflammatory and antioxidant effects, most reports say that supplements do not have any benefits.
No association between vitamin D3/calcium treatment and sudden cognitive impairment or dementia in women over 65 years of treatment with vitamin D3 (400 IU/day) and calcium (1000 mg/day) or condoms (n=4143) and longest trials (sustained for 7.8 years), no vitamin D3/calcium treatment was observed, although the dose of vitamin D3 was low and one fifth of our dose. Therefore, our results are important to show that even higher doses of vitamin D3 do not provide a general intentional cognitive benefit.
Similarly, in two random European trials, vitamin D3 of 2000 IU/day was evaluated for 3 and 2 years among older people living in the community for 3 years and 2 years, and no difference in cognitive function was observed by dry pre-modification compared with vitamin D3 of 2000 IU/day (n=273). Four small studies (n
In a 3-year study of 260 elderly women (65-73 years old), vitamin D3 (personal ingredient dosage ≥ 2400 IU/day to maintain serum 25(OH)D ≥ 30 ng/mL) and calcium (1200 mg/day) and calcium (1200 mg/day) were observed by Owusu et al. There was no difference in the variation in manifestation, similar to our zero findings of general perceptions of black participants.
In the AGG analysis, we observed that among black participants, vitamin D3 supplementation was significantly related to better awareness maintenance in overall ratings and execution/attention ratings. This is consistent with studies that observed that the lack of vitamin D3 is most significantly related to execution function deficits. Although species and baseline blood 25(OH)D were prespecified horizontal interactions, but these assemblies do not adjust multiple comparisons, so careful explanation should be given. We presume that vitamin D3 may be particularly beneficial for black participants with lower baseline time 25(OH)D concentrations; however, the reasons for the specific benefits of black participants remain unclear due to the lack of significant effect corrections for baseline blood 25(OH)D levels in this sub-study and the main trials. Evaluation of future use of new vitamin D biomarkers (e.g., vitamin D binding protein (VDBP) or 25(OH)D) and VDBP gene variations (showing differences in race/ethnic group distribution) may be apparent. In addition, it is worth noting that black participants have higher prevalence of diabetes and other cardiovascular risk factors, and lower baseline blood 25(OH)D level, education level, and baseline awareness ratings, all of which are characteristic benefits of Vitamin D with stronger suggestive Asian groups, especially for executing functions; therefore, the concentration of multiple risk factors for decreased awareness may lead to greater benefits for Black participants for Vitamin D.
In general, vitamin D3 supplementation (2000 IU/day) did not reduce 2-3 years of declining awareness among healthy adults with a generally well-educated, despite the mild benefits that need further certification in black elderly people.
Original text: The relationship between vitamin D and dementia: active/inactive
