Must-eat during the Mid-Autumn Festival! Take "7 drugs" and don t eat grapefruit first. If the time is not open, the interaction will not be completely avoided.

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The Mid-Autumn Festival is coming, and grapefruit is an indispensable fruit for scenery. However, doctors and nutritionists remind that you should not eat too much grapefruit, you can only taste it. Especially those who take seven kinds of drugs such as anticoagulants, blood lipid-lowering drugs, blood pressure lowering drugs, heart arrhythmia drugs, sleeping drugs, inhalation drugs, and immunosuppressive drugs. Be careful about the interaction between "piper" and "medicine".

Pomelo is a "three-high" fruit, and the amount you need to control when eating.

Nutritionist Liu Yili pointed out that grapefruit is a "three-high" fruit with high dietary fiber, high-deep and high vitamin C. It can help gastric tract peristalsis, improve constipation, and lower steroids and blood pressure. It is very suitable for barbecue to eat, and can remove oil from food and help promote reproduction.

However, grapefruit has high moisture content and is a high-desert fruit. If you are not careful, you will easily eat too much. Liu Yili reminds you to control the amount of food. You can eat it at most 4 to 5 petals at a time. It is recommended to eat it with your friends. However, patients with impaired kidney function should not eat it. Children and people with prone to abdominal distension should not eat it too much.

Interaction between grapefruit and anticoagulant drugs may cause gastric aches

Xu Bingyi, deputy director of Annan Hospital and a physician in the gastrointestinal department, said that he met a 75-year-old man who fainted after stool at home during the Mid-Autumn Festival holiday and was sent to emergency clinic. After examination, he found that it was gastric bleeding and the blood was difficult to coagulate. It turned out that he had a "atrial dysfunction" heart rhythm problem. He usually took anticoagulant to prevent cardiac thrombosis. Therefore, when the gastric dysfunction caused by emergency clinician bleeding, the blood did not coagulate and severe bleeding, causing ischemic fainting. After examination, the patient had eaten too much grapefruit and interacted with anticoagulant drugs, causing continuous gastric bleeding.

Xu Bingyi said that grapefruit contains "furanocumarin", which irreversibly inhibits the hepatic enzyme CYP450 3A4, making this hepatic enzyme unable to remove many drugs taken in the body, causing the blood concentration of these drugs that were originally derived from CYP450 3A4, causing side effects of the drug.

The seven common types of drugs are easy to interact with grapefruit

1. Anticoagulant drugs: such as Warfarin (Cofarin, can be used to coagulate), Rivaroxa (Xarelto, Bairetu), Dabigatran (Pradaxa, Pradaxa)

[Side effects] Increase bleeding risks.

2. Hyperlipid-lowering drugs: such as Atorvastatin (Lipitor, Lipitor), Rosuvastatin (Crestor, Simvastatin (Vytorin, Vitorin)

[Side effects] may increase muscle pain, dark urine, and hepatotoxic risks.

3. Lowering blood pressure medicines: such as Nifedipine (Adalat OROS, Amlodipine (Norvasc, Vitiligo)

[Side Effects] Causes blood pressure is too low, hydrated and kidneys are irritated during the week, and the heartbeat is faster.

4. Drugs for cardiac arrhythmia: such as Amiodarone (Cordarone, Chloro), Dronedarone (Multaq, Chloro)

[Side Effects] Cardiac toxicity.

5. Sleeping drugs: such as Diazepam (Dupin, Leping; Sleeping), Trazodone (Mesyrel, Messue), Quetiapine (Seroquel, Silokang)

[Side effects] It is easy to cause dizziness and drowsiness.

6. Anti-inflammatory drugs: such as Carbamazepine (Tegretol, excretion)

[Side effects] Increases allergic risks of drugs.

7. Immunosuppressive agents: such as Cyclosporin (Sandimmun Neoral), Tacrolimus (Prograf, Prograf)

[Side effects] Increase adverse reactions such as nausea, headache, numbness, cramps, and kidney toxicity.

" See more Drug Encyclopedia

Xu Bingyi reminds that people who usually take these drugs should not eat too much grapefruit. In addition, it is worth noting that the inhibitory effect of "peucao" on drug can last for several hours, or even two or three days. Even if the time of "eating grapefruit" and "taking medicine" is incorrect, it is impossible to completely avoid the interaction between grapefruit and medicine.